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Why Vaccination Programs are Changing?

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Why, when you know from personal experience that life-long immunity exists for many human vaccines, do you have great difficulty believing a canine vaccine can also provide life-long immunity? Immunologic memory varies from disease to disease and among different types of vaccines. Immunologic memory is likely to be the same for modified live viral vaccines, as it is from natural immunity, immunity after infection or disease.

Similarly ferret giardia treatment infections and vaccines or bacterins killed bacterial vaccines can provide immunologic memory.

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Immunologic memory to bacteria is generally not as long as to viruses and, in general, ferret giardia treatment memory to killed viral vaccines and to bacterial vaccines or bacterins is not as long lived as it is to MLV vaccines. The duration of immunity or length of immunologic memory varies among the agents causing the diseases. For example, our immunologic memory for measles virus is generally life-long.

How do we know that it is life long? In contrast to the MLV vaccine, the killed measles vaccines that were used for a short period of time about 25 years ago failed to give life-long immunity.

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Many individuals receiving killed vaccines were either inadvertently infected or had to be revaccinated with a MLV when they were 15 to 20 ferret giardia treatment of age. Their exposure to virus or vaccine provided lifelong immunity. How many people do you know that were vaccinated with the modified live measles virus product, in use for approximately 40 years, or that had measles as a child, later developed measles during their life? It is possible, but rarely occurs.

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A very similar story to measles can be told for canine distemper virus CDV in the dog. CDV is in the same virus family as measles virus and rinderpest in cattle and the viruses share many similarities. As you may know, MV veterinary vaccines have been and were available until recently for use in dogs to prevent disease not infection caused by CDV.

Like measles immunity in humans, immunity from canine distemper infection confers immunologic memory resulting in lifelong immunity.

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How do I and my older, wiser and now retired colleagues and canine infectious disease experts, Dr. Max Appel, Dr. Skip Carmichael, and Dr. Larry Swango know that distemper immunity is life long? We know because we had the opportunity to follow dogs that recovered from infection with CDV or puppies that were vaccinated once or twice with MLV CDV and lived for 7 or more years and never developed disease even though they were exposed to CDV via natural outbreaks or experimental challenge with CDV.

We also know the vaccinated or recovered dogs had lifelong immunity because we and others performed antibody tests for years on the dogs after they recovered from infection or after puppy ferret giardia treatment.

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These dogs all had antibody, showing that immunologic ferret giardia treatment was present. Most of the dogs had titers that provide sterile immunity protection from infection much ferret giardia treatment the measles titers after vaccination or natural immunization e.

An antibody titer no matter how low shows the animal has giardia cysts in environment memory since memory effector B cells long-lived plasma cells must be present to produce that antibody.

Some dogs without antibody are protected from disease because they have T cell memory, that will provide cell mediated immunity CMI.

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CMI will not protect from reinfection, but it will prevent disease. When an animal is antibody negative it may have T cell immunologic memory, but I generally consider a CDV antibody negative dog not to be protected, therefore, I recommend revaccination!.

Some researchers, including myself, have had the opportunity to follow the duration of immunity for dogs ferret giardia treatment in natural or experimental environments that are free of CDV and CPV Why is it important that observations are made on dogs and cats that are not exposed to the virus? Because in those environments it is possible to demonstrate that immunologic memory is independent of natural or overt stimulation with the wild type virus or the vaccine virus. If infection does not occur, there is no stimulation of the specific memory T or B cells, thus the antibody titer does not increase.

However, none of more than 50 dams with sick and dying puppies had a significant increase in antibody titer, none had virus in their feces and none showed clinical signs of CPV-2 disease, all excellent indicators the dams had sterile immunity did not get infected!

Is immunologic memory ferret giardia treatment duration of immunity to all human viruses life-long? The answer is NO!

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Natural infection with many human viruses and the vaccines for those viruses provide life-long immunity e. If a puppy is immunized with these three MLV vaccines or the recombinant canarypox vectored CDV to prevent these diseases, there is ferret giardia treatment reason to believe the vaccinated animal will have up to life-long immunity! It is well known in all species that the young animal is more susceptible to infection and disease than a mature animal.

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In the case of human infections that period of increased susceptibility is often the first few years of life, especially the first year.

In the puppy and the kitten it is often the first 3 to 6 months of life, but it can be up to 1 year of age that the animal is more susceptible to disease.

For example, dogs less than a year of age are much more likely to develop severe parvoviral disease than susceptible immunologically naïve dogs and cats over one year of age, even though at both ages the animals are very susceptible to infection with CPV-2 or CPV respectively.

Similarly a susceptible cat less than one year of age and especially cats less than 3 months of age are at much greater risk of becoming persistently infected with feline leukemia virus than a susceptible cat that is greater than one year of age at the time of infection. Thus innate as well as specific immune factors contribute to age-related resistance and these factors are highly complex and not completely understood.

However, age related resistance plays a critical role in life-long or long term immunity. This does not imply that older dogs and cats cannot get infected and develop disease, it is that ferret giardia treatment are much less likely to get disease when compared to the younger animal and if they have been vaccinated as pups or kittens, their immunity should be excellent for up to a lifetime.

It should also be recognized that very old animals, including people, become more susceptible to disease with organisms in the environment that do not generally cause disease when younger people are infected with them.

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GIARDIASIS -- STRUCTURE, LIFE CYCLE, SYMPTOMS, DIAGNOSIS, TREATMENT -- BY PHANINDRA GUPTA

However, that does not mean the old dogs are not at greater risk of infection with certain bacteria that only provide short term immunity. In general, bacterial immunity is shorter lived than viral ferret giardia treatment.

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For example, immunity to cholera from vaccination in humans is 6 months. Bacterial immunity in dogs to leptospirosis and Lyme disease is short lived — one year or less. I and my colleague, Dr.

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Fred Scott, first proposed a three year revaccination program for dogs and cats more than 25 years ago, when we published an article in Veterinary Clinics of North America 8 4 In fact, it may even be difficult to show an immunologic benefit for revaccination at three year intervals since most animals have long ferret giardia treatment immunity for CDV, CAV-1 and CPV Some among you are probably convinced that there is life long immunity to certain vaccines used in dogs and cats, but few of you after many years of performing annual revaccination are willing to take the risk, however small it may be, to adopt my puppy vaccination program—that is, to vaccinate once or twice at an age when naturally derived antibody does block the vaccine.

Revaccination annually with the core vaccines does increase the risk for adverse reactions! You and your client will need to determine what vaccines and vaccination program are best for the animal.

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Your ferret giardia treatment should depend on the life style of the animal, its medical history, health status, age, pregnancy status and other important factors and not on using the vaccine as a practice management tool to get the clients to bring their animals in on an annual or semi-annual basis for a wellness visit.

Is there a risk of over-vaccinating a pet e.

In addition, monitor a platelet count, liver enzymes, and bilirubin prior to each CCNU administration. Thrombocytopenia occurs 21 days following administration. Platelet count should be checked prior to administration of therapy. If the ALT is higher than the ALP, if there is a tremendous increase in these values from the last treatment, if the GGT has increased since last visit, or if there is a hyperbilirubinemia, postpone therapy for 2 weeks and recheck. If there is CCNU toxicity, the values typically decrease.

Yes—vaccines should not be given needlessly, as they may cause adverse reactions. Vaccines are medical products that should be tailored to the needs of the individual animal.

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May I mix different types of vaccines in the syringe? No—one should never mix different vaccine preparations in the syringe unless specified by the data sheet. May I co-inject different vaccines not part of a single commercial product into the same animal? Yes—but ferret giardia treatment vaccines should be injected into separate sites that are drained by different lymph nodes.

May I use smaller vaccine doses in small breeds to reduce the risk of adverse reactions? No—the volume e.